Subsequent studies have shown that historical outbreaks such as influenza, measles, mumps, chicken pox and polio are associated with schizophrenia. In 1964, the incidence of schizophrenia in the population exposed to rubella epidemic increased from 1% to 20%. Modeling this risk factor in animals, when influenza infection is induced in pregnant rodents during pregnancy, their offspring Show several behavioral and histological abnormalities consistent with human mental illness. Numerous animal studies demonstrate that prenatal or early postnatal infections can result in both acute and persistent neurological and behavioral abnormalities in offspring resembling autistic traits or schizophrenia. ![]() Thus, the risk for schizophrenia in the offspring was increased 3-fold by infection in the second trimester. An increase in the amount of viral infection and schizophrenia was detected in winter and spring. The strongest evidence for maternal infection increasing risk for a mental disorder in the offspring is the connection between schizophrenia and maternal respiratory infection. Although schizophrenia was considered a syndrome of different biological backgrounds, the inclusion of immune system disorders may be one of the common mechanisms. The relationship between maternal infection and neurodevelopmental disorders has long been known. Recent findings suggest that there is a relationship between schizophrenia and immune system disorders. We think that these non-returning cells were cause physiopathological Mc. In mammals, the building blocks of brain development are completed before birth. It is known that neurodevelopment in human’s results from the interaction of genetic, epigenetic and environmental factors. There are different interpretations of the functions of these MMcCs that settle in fetal tissues and do not return. The mother’s cell, which passes to protect the fetus, plays a role in the construction of various tissues and organs before returning. Infectious diseases can increase routine cell migration between mother and fetus. In this way, the fetus was protected from viral diseases. As a matter of fact, maternal cells pass from mother to fetus in the first 4.5 months of pregnancy due to viral infections of mother. During the first months of pregnancy, viral infections of the mother is disrupt the physiology. The physiopathological stateĮach physiological event has a physiopathological state. Thus, FPCs appear to undergo a molecular and morphological maturation program similar to that observed during adult neurogenesis. In addition, neuronal maturation of these cells was observed with increasing axonal dendritic complexity. In addition to expressing neural stem cell or immature neuron markers, FPCs were expressed mature neuron markers and indicated that they adopted a neuron fate. In fetal-maternal Mc, it was shown that FPCs were joined with various regions of the maternal brain until the 7 th month after birth and became permanent. However, FPCs were shown to mature and differentiate into neurons in the mother brain. However, the association of these fetal cells (FCs) with the brain, their long-term survival and differentiation are not fully known. The findings support the likelihood that fetal cells frequently cross the human blood-brain barrier and that Mc in the brain is relatively common. Pregnancy-related migratory progenitor fetal cells (FPCs) have been shown to merge with multiple maternal organs. ![]() Mc is also seen as a physiological component of the immune system. Therefore, the physiological task of Mc is a mysterious and incomplete issue. Today, however it is not known exactly why Mc exists or what its task is. Therefore, we were all born microchimerically. The relationship between microchimerism and psychiatric disordersīi-directional cell transfer between mother and fetus during pregnancy is a physiological phenomenon (Figure 1). It has been predicted that younger siblings could also obtain older siblings’ cells, as depicted with offspring 1 cells (orange) circulating within the younger sibling’s body (offspring 2). Likewise, each fetus inherits maternally derived cells (represented as purple circles). During pregnancy, fetal cells (represented as orange and green circles) traffic into the maternal body, increasing in quantity throughout the gestational period.
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